TY  - GEN
AU  - Prajapati,Sabin
AU  - Haselbach,David
AU  - Wittig,Sabine
AU  - Patel,Mulchand S
AU  - Chari,Ashwin
AU  - Schmidt,Carla
AU  - Stark,Holger
AU  - Tittmann,Kai
TI  - Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters
SN  - 1878-4186
PY  - 2020///0427
KW  - Acetyl Coenzyme A
KW  - chemistry
KW  - Catalytic Domain
KW  - Cloning, Molecular
KW  - Coenzyme A
KW  - Cryoelectron Microscopy
KW  - Escherichia coli
KW  - genetics
KW  - Gene Expression
KW  - Genetic Vectors
KW  - Humans
KW  - Kinetics
KW  - Models, Molecular
KW  - Protein Binding
KW  - Protein Conformation, alpha-Helical
KW  - Protein Conformation, beta-Strand
KW  - Protein Interaction Domains and Motifs
KW  - Protein Multimerization
KW  - Protein Subunits
KW  - Pyruvate Dehydrogenase Complex
KW  - Recombinant Proteins
KW  - Substrate Specificity
KW  - Thermodynamics
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.str.2019.04.009
ER  -