TY  - GEN
AU  - Zhou,Zhuan
AU  - Feng,Zhiwei
AU  - Hu,Dong
AU  - Yang,Peng
AU  - Gur,Mert
AU  - Bahar,Ivet
AU  - Cristofanilli,Massimo
AU  - Gradishar,William J
AU  - Xie,Xiang-Qun
AU  - Wan,Yong
TI  - A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy
SN  - 2352-3964
PY  - 2019///1218
KW  - Animals
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Cell Line
KW  - Cell Line, Tumor
KW  - Cell Survival
KW  - drug effects
KW  - DNA Damage
KW  - DNA Methylation
KW  - Dose-Response Relationship, Drug
KW  - Drug Discovery
KW  - Enzyme Inhibitors
KW  - chemistry
KW  - Epigenesis, Genetic
KW  - Female
KW  - Gene Expression Regulation, Neoplastic
KW  - Humans
KW  - Immunohistochemistry
KW  - Kruppel-Like Factor 4
KW  - Kruppel-Like Transcription Factors
KW  - genetics
KW  - Mice
KW  - Models, Molecular
KW  - Molecular Conformation
KW  - Molecular Targeted Therapy
KW  - Neoplastic Stem Cells
KW  - metabolism
KW  - Protein-Arginine N-Methyltransferases
KW  - antagonists & inhibitors
KW  - Recombinant Fusion Proteins
KW  - Structure-Activity Relationship
KW  - Substrate Specificity
KW  - Triple Negative Breast Neoplasms
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.ebiom.2019.05.011
ER  -