Zhou, Zhuan <br/><br/>
A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy.  [electronic resource] 

 -  EBioMedicine  Jun 2019 
 - 98-111 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>2352-3964 
<br/><br/><label>Standard No.: </label>10.1016/j.ebiom.2019.05.011  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--pharmacology<br/>Cell Line<br/>Cell Line, Tumor<br/>Cell Survival--drug effects<br/>DNA Damage<br/>DNA Methylation--drug effects<br/>Dose-Response Relationship, Drug<br/>Drug Discovery<br/>Enzyme Inhibitors--chemistry<br/>Epigenesis, Genetic--drug effects<br/>Female<br/>Gene Expression Regulation, Neoplastic--drug effects<br/>Humans<br/>Immunohistochemistry<br/>Kruppel-Like Factor 4<br/>Kruppel-Like Transcription Factors--genetics<br/>Mice<br/>Models, Molecular<br/>Molecular Conformation<br/>Molecular Targeted Therapy<br/>Neoplastic Stem Cells--metabolism<br/>Protein-Arginine N-Methyltransferases--antagonists & inhibitors<br/>Recombinant Fusion Proteins<br/>Structure-Activity Relationship<br/>Substrate Specificity<br/>Triple Negative Breast Neoplasms--genetics<br/>Xenograft Model Antitumor Assays