TY  - GEN
AU  - O'Reilly,Molly
AU  - Kirkwood,Nerissa K
AU  - Kenyon,Emma J
AU  - Huckvale,Rosemary
AU  - Cantillon,Daire M
AU  - Waddell,Simon J
AU  - Ward,Simon E
AU  - Richardson,Guy P
AU  - Kros,Corné J
AU  - Derudas,Marco
TI  - Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel
SN  - 1520-4804
PY  - 2020///0615
KW  - Aminoglycosides
KW  - adverse effects
KW  - Animals
KW  - Carvedilol
KW  - chemical synthesis
KW  - Chemistry Techniques, Synthetic
KW  - Cytoprotection
KW  - drug effects
KW  - Dose-Response Relationship, Drug
KW  - Drug Design
KW  - Electrophysiological Phenomena
KW  - Hair Cells, Auditory
KW  - cytology
KW  - Mechanotransduction, Cellular
KW  - Mice
KW  - Zebrafish
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/acs.jmedchem.8b01325
ER  -