TY  - GEN
AU  - Skinner-Adams,Tina S
AU  - Fisher,Gillian M
AU  - Riches,Andrew G
AU  - Hutt,Oliver E
AU  - Jarvis,Karen E
AU  - Wilson,Tony
AU  - von Itzstein,Mark
AU  - Chopra,Pradeep
AU  - Antonova-Koch,Yevgeniya
AU  - Meister,Stephan
AU  - Winzeler,Elizabeth A
AU  - Clarke,Mary
AU  - Fidock,David A
AU  - Burrows,Jeremy N
AU  - Ryan,John H
AU  - Andrews,Katherine T
TI  - Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone
SN  - 2399-3642
PY  - 2020///0420
KW  - Animals
KW  - Anopheles
KW  - Antimalarials
KW  - chemistry
KW  - Atovaquone
KW  - Cyclization
KW  - drug effects
KW  - Dihydroorotate Dehydrogenase
KW  - Dose-Response Relationship, Drug
KW  - Drug Combinations
KW  - Electron Transport Complex III
KW  - antagonists & inhibitors
KW  - Enzyme Inhibitors
KW  - Erythrocytes
KW  - Folic Acid
KW  - metabolism
KW  - Hep G2 Cells
KW  - Humans
KW  - Inhibitory Concentration 50
KW  - Liver
KW  - Oxidoreductases Acting on CH-CH Group Donors
KW  - Plasmodium berghei
KW  - Plasmodium falciparum
KW  - Proguanil
KW  - analogs & derivatives
KW  - Sporozoites
KW  - Terpenes
KW  - Triazines
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s42003-019-0397-3
ER  -