Skinner-Adams, Tina S <br/><br/>
Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone.  [electronic resource] 

 -  Communications biology  2019 
 - 166 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>2399-3642 
<br/><br/><label>Standard No.: </label>10.1038/s42003-019-0397-3  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Anopheles<br/>Antimalarials--chemistry<br/>Atovaquone--chemistry<br/>Cyclization--drug effects<br/>Dihydroorotate Dehydrogenase<br/>Dose-Response Relationship, Drug<br/>Drug Combinations<br/>Electron Transport Complex III--antagonists & inhibitors<br/>Enzyme Inhibitors--chemistry<br/>Erythrocytes--drug effects<br/>Folic Acid--metabolism<br/>Hep G2 Cells<br/>Humans<br/>Inhibitory Concentration 50<br/>Liver--drug effects<br/>Oxidoreductases Acting on CH-CH Group Donors--metabolism<br/>Plasmodium berghei--drug effects<br/>Plasmodium falciparum--drug effects<br/>Proguanil--analogs & derivatives<br/>Sporozoites--drug effects<br/>Terpenes--metabolism<br/>Triazines--chemistry