Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression. [electronic resource]
- Journal of neurovirology 08 2019
- 508-519 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1538-2443
10.1007/s13365-019-00751-0 doi
Astrocytes--drug effects Cell Line, Tumor Enhancer of Zeste Homolog 2 Protein--antagonists & inhibitors Fibroblasts--drug effects Gene Expression Regulation Genes, Reporter Green Fluorescent Proteins--genetics HEK293 Cells HIV-1--drug effects Histones--genetics Host-Pathogen Interactions--drug effects Humans Indoles--pharmacology Jurkat Cells Luminescent Proteins--genetics Methyl-CpG-Binding Protein 2--genetics Methylation Pyridones--pharmacology Signal Transduction Vesiculovirus--genetics Virus Latency--drug effects tat Gene Products, Human Immunodeficiency Virus--genetics Red Fluorescent Protein