TY - GEN AU - Siddiqi,Farah H AU - Menzies,Fiona M AU - Lopez,Ana AU - Stamatakou,Eleanna AU - Karabiyik,Cansu AU - Ureshino,Rodrigo AU - Ricketts,Thomas AU - Jimenez-Sanchez,Maria AU - Esteban,Miguel Angel AU - Lai,Liangxue AU - Tortorella,Micky D AU - Luo,Zhiwei AU - Liu,Hao AU - Metzakopian,Emmanouil AU - Fernandes,Hugo J R AU - Bassett,Andrew AU - Karran,Eric AU - Miller,Bruce L AU - Fleming,Angeleen AU - Rubinsztein,David C TI - Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing SN - 2041-1723 PY - 2019///0528 KW - Animals KW - Animals, Genetically Modified KW - Autophagy KW - drug effects KW - Cell Line KW - Cerebral Cortex KW - cytology KW - Disease Models, Animal KW - Drug Repositioning KW - Embryo, Mammalian KW - Embryo, Nonmammalian KW - Felodipine KW - pharmacology KW - Female KW - Humans KW - Induced Pluripotent Stem Cells KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Mutation KW - Neurodegenerative Diseases KW - drug therapy KW - Neurons KW - Neuroprotective Agents KW - Primary Cell Culture KW - Swine KW - Swine, Miniature KW - Treatment Outcome KW - Zebrafish KW - alpha-Synuclein KW - genetics N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/s41467-019-09494-2 ER -