TY - GEN AU - Kato,Taro AU - Pothula,Santosh AU - Liu,Rong-Jian AU - Duman,Catharine H AU - Terwilliger,Rosemarie AU - Vlasuk,George P AU - Saiah,Eddine AU - Hahm,Seung AU - Duman,Ronald S TI - Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation SN - 1558-8238 PY - 2020///0413 KW - Animals KW - Antidepressive Agents KW - chemistry KW - Behavior, Animal KW - drug effects KW - Brain-Derived Neurotrophic Factor KW - genetics KW - Heat-Shock Proteins KW - Male KW - Mechanistic Target of Rapamycin Complex 1 KW - Mice KW - Mice, Knockout KW - Rats KW - Rats, Sprague-Dawley KW - Synaptic Transmission N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1172/JCI126859 ER -