TY  - GEN
AU  - Hu,Jiantao
AU  - Hu,Biao
AU  - Wang,Mingliang
AU  - Xu,Fuming
AU  - Miao,Bukeyan
AU  - Yang,Chao-Yie
AU  - Wang,Mi
AU  - Liu,Zhaomin
AU  - Hayes,Daniel F
AU  - Chinnaswamy,Krishnapriya
AU  - Delproposto,James
AU  - Stuckey,Jeanne
AU  - Wang,Shaomeng
TI  - Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)
SN  - 1520-4804
PY  - 2020///0303
KW  - Antineoplastic Agents
KW  - chemical synthesis
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - drug effects
KW  - Dipeptides
KW  - Drug Design
KW  - Drug Screening Assays, Antitumor
KW  - Humans
KW  - Ligands
KW  - Molecular Structure
KW  - Proteolysis
KW  - Pyrrolidines
KW  - Receptors, Estrogen
KW  - chemistry
KW  - Structure-Activity Relationship
KW  - Thiophenes
KW  - Ubiquitin-Protein Ligases
KW  - metabolism
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/acs.jmedchem.8b01572
ER  -