Hu, Jiantao <br/><br/>
Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER).  [electronic resource] 

 -  Journal of medicinal chemistry  02 2019 
 - 1420-1442 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.8b01572  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antineoplastic Agents--chemical synthesis<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Dipeptides--chemical synthesis<br/>Drug Design<br/>Drug Screening Assays, Antitumor<br/>Humans<br/>Ligands<br/>Molecular Structure<br/>Proteolysis<br/>Pyrrolidines--chemical synthesis<br/>Receptors, Estrogen--chemistry<br/>Structure-Activity Relationship<br/>Thiophenes--chemical synthesis<br/>Ubiquitin-Protein Ligases--metabolism