Methot, Joey L <br/><br/>
Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability.  [electronic resource] 

 -  Journal of medicinal chemistry  05 2019 
 - 4370-4382 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.8b01818  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Class Ia Phosphatidylinositol 3-Kinase--metabolism<br/>Dogs<br/>Drug Design<br/>HeLa Cells<br/>Humans<br/>Male<br/>Protein Kinase Inhibitors--chemical synthesis<br/>Purines--chemical synthesis<br/>Pyrrolidines--chemical synthesis<br/>Rats, Wistar