TY - GEN AU - Zhang,Dongxu AU - Liu,Houxian AU - Yang,Binbin AU - Hu,Jiasheng AU - Cheng,Yue TI - L-securinine inhibits cell growth and metastasis of human androgen-independent prostate cancer DU145 cells via regulating mitochondrial and AGTR1/MEK/ERK/STAT3/PAX2 apoptotic pathways SN - 1573-4935 PY - 2020///0706 KW - Antineoplastic Agents, Phytogenic KW - pharmacology KW - Apoptosis KW - drug effects KW - Azepines KW - Caspase 3 KW - genetics KW - Caspase 9 KW - Cell Cycle KW - Cell Line, Tumor KW - Cell Movement KW - Cell Proliferation KW - Gene Expression Regulation, Neoplastic KW - Heterocyclic Compounds, Bridged-Ring KW - Humans KW - Lactones KW - MAP Kinase Kinase 1 KW - MAP Kinase Kinase 2 KW - Male KW - Mitochondria KW - Mitogen-Activated Protein Kinase 1 KW - Mitogen-Activated Protein Kinase 3 KW - PAX2 Transcription Factor KW - Piperidines KW - Prostatic Neoplasms, Castration-Resistant KW - drug therapy KW - Receptor, Angiotensin, Type 1 KW - STAT3 Transcription Factor KW - Signal Transduction KW - bcl-2-Associated X Protein N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1042/BSR20190469 ER -