The CTLA-4 x OX40 bispecific antibody ATOR-1015 induces anti-tumor effects through tumor-directed immune activation. [electronic resource]
- Journal for immunotherapy of cancer 04 2019
- 103 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2051-1426
10.1186/s40425-019-0570-8 doi
Animals Antibodies, Bispecific--pharmacology CHO Cells CTLA-4 Antigen--antagonists & inhibitors Cell Line, Tumor--transplantation Cricetulus Disease Models, Animal Drug Screening Assays, Antitumor Female HEK293 Cells Humans Male Mice Mice, Transgenic Primary Cell Culture Proof of Concept Study Receptors, OX40--agonists T-Lymphocytes, Regulatory--drug effects Urinary Bladder Neoplasms--drug therapy