PARP Inhibitor Protects Against Chronic Hypoxia/Reoxygenation-Induced Retinal Injury by Regulation of MAPKs, HIF1α, Nrf2, and NFκB. [electronic resource]
- Investigative ophthalmology & visual science 04 2019
- 1478-1490 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1552-5783
10.1167/iovs.18-25936 doi
Animals Chronic Disease Cytokines--metabolism Disease Models, Animal Fluorescent Antibody Technique, Indirect Hypoxia--complications Hypoxia-Inducible Factor 1, alpha Subunit--metabolism Immunoblotting Intercellular Signaling Peptides and Proteins--metabolism Male NF-E2-Related Factor 2--metabolism NF-kappa B--metabolism Oxidative Stress Oxygen--toxicity Phosphorylation Phthalazines--therapeutic use Piperazines--therapeutic use Poly (ADP-Ribose) Polymerase-1--antagonists & inhibitors Poly(ADP-ribose) Polymerase Inhibitors--therapeutic use Rats Rats, Wistar Reactive Oxygen Species--metabolism Reperfusion Injury--metabolism Retinal Diseases--metabolism p38 Mitogen-Activated Protein Kinases--metabolism