TY  - GEN
AU  - Al-Qahtani,Alanod D
AU  - Bashraheel,Sara S
AU  - Rashidi,Fatma B
AU  - O'Connor,C David
AU  - Romero,Atilio Reyes
AU  - Domling,Alexander
AU  - Goda,Sayed K
TI  - Production of "biobetter" variants of glucarpidase with enhanced enzyme activity
SN  - 1950-6007
PY  - 2019///0903
KW  - Antimetabolites, Antineoplastic
KW  - adverse effects
KW  - Cloning, Molecular
KW  - Drug Design
KW  - Enzyme Stability
KW  - Enzyme Therapy
KW  - methods
KW  - Methotrexate
KW  - Models, Molecular
KW  - Neoplasms
KW  - drug therapy
KW  - Point Mutation
KW  - Prodrugs
KW  - administration & dosage
KW  - Pseudomonas putida
KW  - genetics
KW  - Recombinant Proteins
KW  - gamma-Glutamyl Hydrolase
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.biopha.2019.108725
ER  -