Al-Qahtani, Alanod D Production of "biobetter" variants of glucarpidase with enhanced enzyme activity. [electronic resource] - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Apr 2019 - 108725 p. digital Publication Type: Journal Article ISSN: 1950-6007 Standard No.: 10.1016/j.biopha.2019.108725 doi Subjects--Topical Terms: Antimetabolites, Antineoplastic--adverse effectsCloning, MolecularDrug DesignEnzyme StabilityEnzyme Therapy--methodsMethotrexate--adverse effectsModels, MolecularNeoplasms--drug therapyPoint MutationProdrugs--administration & dosagePseudomonas putida--geneticsRecombinant Proteins--geneticsgamma-Glutamyl Hydrolase--genetics