Kahl, Dylan J <br/><br/>
5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma.  [electronic resource] 

 -  Journal of medicinal chemistry  05 2019 
 - 4350-4369 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.8b01772  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Carboxylic Acids--chemical synthesis<br/>Connective Tissue Growth Factor--metabolism<br/>Enzyme Inhibitors--chemical synthesis<br/>Female<br/>Fibrosis--drug therapy<br/>Mice, Inbred C57BL<br/>Microsomes, Liver--drug effects<br/>Molecular Structure<br/>Oxadiazoles--chemical synthesis<br/>Scleroderma, Systemic--drug therapy<br/>Serum Response Factor--antagonists & inhibitors<br/>Signal Transduction--drug effects<br/>Skin--pathology<br/>Structure-Activity Relationship<br/>Trans-Activators--antagonists & inhibitors<br/>Transcription, Genetic--drug effects<br/>rho GTP-Binding Proteins--antagonists & inhibitors