TY  - GEN
AU  - Christian,Sven
AU  - Merz,Claudia
AU  - Evans,Laura
AU  - Gradl,Stefan
AU  - Seidel,Henrik
AU  - Friberg,Anders
AU  - Eheim,Ashley
AU  - Lejeune,Pascale
AU  - Brzezinka,Krzysztof
AU  - Zimmermann,Katja
AU  - Ferrara,Steven
AU  - Meyer,Hanna
AU  - Lesche,Ralf
AU  - Stoeckigt,Detlef
AU  - Bauser,Marcus
AU  - Haegebarth,Andrea
AU  - Sykes,David B
AU  - Scadden,David T
AU  - Losman,Julie-Aurore
AU  - Janzer,Andreas
TI  - The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies
SN  - 1476-5551
PY  - 2020///0203
KW  - Animals
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Apoptosis
KW  - drug effects
KW  - Cell Differentiation
KW  - Cell Line, Tumor
KW  - Dihydroorotate Dehydrogenase
KW  - Enzyme Inhibitors
KW  - Female
KW  - HL-60 Cells
KW  - Humans
KW  - Leukemia, Myeloid, Acute
KW  - drug therapy
KW  - Leukemia, Promyelocytic, Acute
KW  - Mice
KW  - Mice, Inbred NOD
KW  - Mice, SCID
KW  - Oxidoreductases Acting on CH-CH Group Donors
KW  - antagonists & inhibitors
KW  - Pyrimidines
KW  - metabolism
KW  - THP-1 Cells
KW  - Translocation, Genetic
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1038/s41375-019-0461-5
ER  -