TY  - GEN
AU  - Begg,Malcolm
AU  - Edwards,Chris D
AU  - Hamblin,J Nicole
AU  - Pefani,Eleni
AU  - Wilson,Robert
AU  - Gilbert,Jane
AU  - Vitulli,Giovanni
AU  - Mallett,David
AU  - Morrell,Josie
AU  - Hingle,Martin I
AU  - Uddin,Sorif
AU  - Ehtesham,Filzah
AU  - Marotti,Miriam
AU  - Harrell,Andrew
AU  - Newman,Carla F
AU  - Fernando,Disala
AU  - Clark,Jonathan
AU  - Cahn,Anthony
AU  - Hessel,Edith M
TI  - Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase 
SN  - 1521-0103
PY  - 2019///1230
KW  - Administration, Inhalation
KW  - Adult
KW  - Animals
KW  - Bronchoalveolar Lavage
KW  - Eosinophilia
KW  - drug therapy
KW  - Female
KW  - Humans
KW  - Indazoles
KW  - administration & dosage
KW  - Lung
KW  - metabolism
KW  - Male
KW  - Mice
KW  - Middle Aged
KW  - Permeability
KW  - Phosphoinositide-3 Kinase Inhibitors
KW  - Safety
KW  - Solubility
KW  - Sputum
KW  - drug effects
KW  - Sulfonamides
KW  - Translational Research, Biomedical
N1  - Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1124/jpet.119.257311
ER  -