TY  - GEN
AU  - Hernandez,Israel
AU  - Luna,Gabriel
AU  - Rauch,Jennifer N
AU  - Reis,Surya A
AU  - Giroux,Michel
AU  - Karch,Celeste M
AU  - Boctor,Daniel
AU  - Sibih,Youssef E
AU  - Storm,Nadia J
AU  - Diaz,Antonio
AU  - Kaushik,Susmita
AU  - Zekanowski,Cezary
AU  - Kang,Alexander A
AU  - Hinman,Cassidy R
AU  - Cerovac,Vesna
AU  - Guzman,Elmer
AU  - Zhou,Honjun
AU  - Haggarty,Stephen J
AU  - Goate,Alison M
AU  - Fisher,Steven K
AU  - Cuervo,Ana M
AU  - Kosik,Kenneth S
TI  - A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy
SN  - 1946-6242
PY  - 2020///0427
KW  - Animals
KW  - Brain
KW  - drug effects
KW  - Disease Models, Animal
KW  - Enzyme Inhibitors
KW  - pharmacology
KW  - Farnesyltranstransferase
KW  - antagonists & inhibitors
KW  - Female
KW  - GTP-Binding Proteins
KW  - Humans
KW  - Induced Pluripotent Stem Cells
KW  - Lysosomes
KW  - Male
KW  - Mice
KW  - Mice, Transgenic
KW  - Mutation
KW  - Neurons
KW  - Piperidines
KW  - Proteolysis
KW  - Pyridines
KW  - RNA, Small Interfering
KW  - genetics
KW  - Tauopathies
KW  - drug therapy
KW  - Translational Research, Biomedical
KW  - tau Proteins
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1126/scitranslmed.aat3005
ER  -