Zeng, Chen-Ye <br/><br/>
Lentiviral vector-mediated overexpression of Klotho in the brain improves Alzheimer's disease-like pathology and cognitive deficits in mice.  [electronic resource] 

 -  Neurobiology of aging  06 2019 
 - 18-28 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1558-1497 
<br/><br/><label>Standard No.: </label>10.1016/j.neurobiolaging.2019.02.003  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Alzheimer Disease--genetics<br/>Amyloid beta-Peptides--metabolism<br/>Animals<br/>Autophagy<br/>Brain--metabolism<br/>Cognitive Dysfunction--genetics<br/>Disease Models, Animal<br/>Gene Expression<br/>Genetic Therapy--methods<br/>Genetic Vectors--administration & dosage<br/>Glucuronidase--administration & dosage<br/>Humans<br/>Injections, Intraventricular<br/>Klotho Proteins<br/>Lentivirus<br/>Male<br/>Mice, Inbred C57BL<br/>Mice, Transgenic<br/>Microglia--metabolism<br/>Proto-Oncogene Proteins c-akt--antagonists & inhibitors<br/>TOR Serine-Threonine Kinases--antagonists & inhibitors<br/>Up-Regulation