BLT-Immune Humanized Mice as a Model for Nivolumab-Induced Immune-Mediated Adverse Events: Comparison of the NOG and NOG-EXL Strains. [electronic resource]
- Toxicological sciences : an official journal of the Society of Toxicology 05 2019
- 194-208 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
1096-0929
10.1093/toxsci/kfz045 doi
Animals Antineoplastic Agents, Immunological--toxicity Bone Marrow Transplantation Female Genotype Humans Immune System--drug effects Liver Transplantation Lymphocyte Activation--drug effects Mice, Inbred NOD Mice, Transgenic Nivolumab--toxicity Programmed Cell Death 1 Receptor--antagonists & inhibitors Signal Transduction Species Specificity T-Lymphocytes--drug effects Thymus Gland--immunology