TY - GEN AU - Cullot,Grégoire AU - Boutin,Julian AU - Toutain,Jérôme AU - Prat,Florence AU - Pennamen,Perrine AU - Rooryck,Caroline AU - Teichmann,Martin AU - Rousseau,Emilie AU - Lamrissi-Garcia,Isabelle AU - Guyonnet-Duperat,Véronique AU - Bibeyran,Alice AU - Lalanne,Magalie AU - Prouzet-Mauléon,Valérie AU - Turcq,Béatrice AU - Ged,Cécile AU - Blouin,Jean-Marc AU - Richard,Emmanuel AU - Dabernat,Sandrine AU - Moreau-Gaudry,François AU - Bedel,Aurélie TI - CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations SN - 2041-1723 PY - 2019///0403 KW - CRISPR-Associated Protein 9 KW - genetics KW - CRISPR-Cas Systems KW - Chromosome Deletion KW - Chromosomes, Human, Pair 10 KW - Clustered Regularly Interspaced Short Palindromic Repeats KW - DNA KW - DNA Breaks, Double-Stranded KW - Deoxyribonuclease I KW - Fibroblasts KW - cytology KW - Gene Editing KW - methods KW - Genetic Therapy KW - Genome, Human KW - HEK293 Cells KW - High-Throughput Nucleotide Sequencing KW - Humans KW - K562 Cells KW - Models, Biological KW - Porphyria, Erythropoietic KW - Primary Cell Culture KW - RNA, Guide, CRISPR-Cas Systems KW - Recombinational DNA Repair KW - Tumor Suppressor Protein p53 KW - Uroporphyrinogen III Synthetase N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/s41467-019-09006-2 ER -