Abou-Salim, Mahrous A <br/><br/>
Design, synthesis and biological study of hybrid drug candidates of nitric oxide releasing cucurbitacin-inspired estrone analogs for treatment of hepatocellular carcinoma.  [electronic resource] 

 -  Bioorganic chemistry  04 2019 
 - 515-533 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1090-2120 
<br/><br/><label>Standard No.: </label>10.1016/j.bioorg.2019.01.068  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antineoplastic Agents--chemical synthesis<br/>Carcinoma, Hepatocellular--drug therapy<br/>Cucurbitacins--chemical synthesis<br/>Drug Design<br/>Drug Screening Assays, Antitumor<br/>Estrone--analogs & derivatives<br/>G1 Phase Cell Cycle Checkpoints--drug effects<br/>Hep G2 Cells<br/>Humans<br/>Liver Neoplasms--drug therapy<br/>MAP Kinase Signaling System--drug effects<br/>Molecular Docking Simulation<br/>Molecular Structure<br/>Multidrug Resistance-Associated Protein 2<br/>Multidrug Resistance-Associated Proteins--antagonists & inhibitors<br/>Nitric Oxide--metabolism<br/>Nitric Oxide Donors--chemical synthesis<br/>Structure-Activity Relationship