Shi, Chenghui <br/><br/>
Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria.  [electronic resource] 

 -  Journal of medicinal chemistry  03 2019 
 - 2950-2973 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.8b01750  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Anti-Bacterial Agents--chemistry<br/>DNA Gyrase--drug effects<br/>Dogs<br/>Drug Design<br/>Drug Resistance, Multiple, Bacterial--drug effects<br/>Gram-Positive Bacteria--drug effects<br/>Gram-Positive Bacterial Infections--drug therapy<br/>Humans<br/>Mice<br/>Microbial Sensitivity Tests<br/>Rats<br/>Spiro Compounds--chemistry<br/>Structure-Activity Relationship<br/>Topoisomerase II Inhibitors--chemistry