TY  - GEN
AU  - Mengwasser,Kristen E
AU  - Adeyemi,Richard O
AU  - Leng,Yumei
AU  - Choi,Mei Yuk
AU  - Clairmont,Connor
AU  - D'Andrea,Alan D
AU  - Elledge,Stephen J
TI  - Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets
SN  - 1097-4164
PY  - 2019///0624
KW  - Ataxia Telangiectasia Mutated Proteins
KW  - genetics
KW  - BRCA1 Protein
KW  - BRCA2 Protein
KW  - CRISPR-Cas Systems
KW  - Cell Death
KW  - Cell Line, Tumor
KW  - DNA Damage
KW  - DNA End-Joining Repair
KW  - DNA-(Apurinic or Apyrimidinic Site) Lyase
KW  - Endonucleases
KW  - Flap Endonucleases
KW  - Gene Expression Regulation, Neoplastic
KW  - Genes, Lethal
KW  - Humans
KW  - Multifunctional Enzymes
KW  - Neoplasms
KW  - drug therapy
KW  - Poly(ADP-ribose) Polymerase Inhibitors
KW  - pharmacology
KW  - Proliferating Cell Nuclear Antigen
KW  - Protein Binding
KW  - Protein Interaction Domains and Motifs
KW  - RNA Interference
KW  - RNA, Small Interfering
KW  - Synthetic Lethal Mutations
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1016/j.molcel.2018.12.008
ER  -