Mengwasser, Kristen E

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. [electronic resource] - Molecular cell 03 2019 - 885-899.e6 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

1097-4164

10.1016/j.molcel.2018.12.008 doi


Ataxia Telangiectasia Mutated Proteins--genetics
BRCA1 Protein--genetics
BRCA2 Protein--genetics
CRISPR-Cas Systems
Cell Death
Cell Line, Tumor
DNA Damage
DNA End-Joining Repair
DNA-(Apurinic or Apyrimidinic Site) Lyase--genetics
Endonucleases
Flap Endonucleases--genetics
Gene Expression Regulation, Neoplastic
Genes, Lethal
Humans
Multifunctional Enzymes
Neoplasms--drug therapy
Poly(ADP-ribose) Polymerase Inhibitors--pharmacology
Proliferating Cell Nuclear Antigen--genetics
Protein Binding
Protein Interaction Domains and Motifs
RNA Interference
RNA, Small Interfering--genetics
Synthetic Lethal Mutations