TY  - GEN
AU  - Zhang,Haijiao
AU  - Savage,Samantha
AU  - Schultz,Anna Reister
AU  - Bottomly,Daniel
AU  - White,Libbey
AU  - Segerdell,Erik
AU  - Wilmot,Beth
AU  - McWeeney,Shannon K
AU  - Eide,Christopher A
AU  - Nechiporuk,Tamilla
AU  - Carlos,Amy
AU  - Henson,Rachel
AU  - Lin,Chenwei
AU  - Searles,Robert
AU  - Ho,Hoang
AU  - Lam,Yee Ling
AU  - Sweat,Richard
AU  - Follit,Courtney
AU  - Jain,Vinay
AU  - Lind,Evan
AU  - Borthakur,Gautam
AU  - Garcia-Manero,Guillermo
AU  - Ravandi,Farhad
AU  - Kantarjian,Hagop M
AU  - Cortes,Jorge
AU  - Collins,Robert
AU  - Buelow,Daelynn R
AU  - Baker,Sharyn D
AU  - Druker,Brian J
AU  - Tyner,Jeffrey W
TI  - Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms
SN  - 2041-1723
PY  - 2019///0219
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Animals
KW  - Antineoplastic Combined Chemotherapy Protocols
KW  - pharmacology
KW  - Benzimidazoles
KW  - Cell Line, Tumor
KW  - Drug Resistance, Neoplasm
KW  - genetics
KW  - Drug Screening Assays, Antitumor
KW  - Epigenesis, Genetic
KW  - drug effects
KW  - Female
KW  - GTP Phosphohydrolases
KW  - HEK293 Cells
KW  - Humans
KW  - Inhibitory Concentration 50
KW  - Isocitrate Dehydrogenase
KW  - Leukemia, Myeloid, Acute
KW  - drug therapy
KW  - Male
KW  - Membrane Proteins
KW  - Mice
KW  - Middle Aged
KW  - Mutation
KW  - Piperidines
KW  - Protein Kinase Inhibitors
KW  - Pyridones
KW  - Pyrimidinones
KW  - Tandem Repeat Sequences
KW  - Treatment Outcome
KW  - Exome Sequencing
KW  - fms-Like Tyrosine Kinase 3
N1  - Publication Type: Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s41467-018-08263-x
ER  -