Zhang, Haijiao <br/><br/>
Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms.  [electronic resource] 

 -  Nature communications  01 2019 
 - 244 p.  digital 
<br/><br/> Publication Type: Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>2041-1723 
<br/><br/><label>Standard No.: </label>10.1038/s41467-018-08263-x  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adult<br/>Aged<br/>Aged, 80 and over<br/>Animals<br/>Antineoplastic Combined Chemotherapy Protocols--pharmacology<br/>Benzimidazoles--pharmacology<br/>Cell Line, Tumor<br/>Drug Resistance, Neoplasm--genetics<br/>Drug Screening Assays, Antitumor<br/>Epigenesis, Genetic--drug effects<br/>Female<br/>GTP Phosphohydrolases--genetics<br/>HEK293 Cells<br/>Humans<br/>Inhibitory Concentration 50<br/>Isocitrate Dehydrogenase--genetics<br/>Leukemia, Myeloid, Acute--drug therapy<br/>Male<br/>Membrane Proteins--genetics<br/>Mice<br/>Middle Aged<br/>Mutation--drug effects<br/>Piperidines--pharmacology<br/>Protein Kinase Inhibitors--pharmacology<br/>Pyridones--pharmacology<br/>Pyrimidinones--pharmacology<br/>Tandem Repeat Sequences--genetics<br/>Treatment Outcome<br/>Exome Sequencing<br/>fms-Like Tyrosine Kinase 3--genetics