TY  - GEN
AU  - Zhang,Dongfeng
AU  - Lin,Yun
AU  - Chen,Xi
AU  - Zhao,Wenting
AU  - Chen,Dongni
AU  - Gao,Meng
AU  - Wang,Qinglin
AU  - Wang,Bin
AU  - Huang,Haihong
AU  - Lu,Yongjun
AU  - Lu,Yu
TI  - Docking- and pharmacophore-based virtual screening for the identification of novel Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with a thiobarbiturate scaffold
SN  - 1090-2120
PY  - 2020///0203
KW  - Animals
KW  - Antitubercular Agents
KW  - chemical synthesis
KW  - Bacterial Proteins
KW  - antagonists & inhibitors
KW  - Catalytic Domain
KW  - Cell Line
KW  - Drug Evaluation, Preclinical
KW  - Enzyme Inhibitors
KW  - Humans
KW  - Mice
KW  - Microsomes, Liver
KW  - metabolism
KW  - Molecular Docking Simulation
KW  - Molecular Structure
KW  - Mycobacterium tuberculosis
KW  - drug effects
KW  - Protein Binding
KW  - Protein Tyrosine Phosphatases
KW  - Structure-Activity Relationship
KW  - Thiobarbiturates
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.bioorg.2018.12.038
ER  -