TY  - GEN
AU  - Karvonen,Hanna
AU  - Perttilä,Robert
AU  - Niininen,Wilhelmiina
AU  - Hautanen,Veera
AU  - Barker,Harlan
AU  - Murumägi,Astrid
AU  - Heckman,Caroline A
AU  - Ungureanu,Daniela
TI  - Wnt5a and ROR1 activate non-canonical Wnt signaling via RhoA in TCF3-PBX1 acute lymphoblastic leukemia and highlight new treatment strategies via Bcl-2 co-targeting
SN  - 1476-5594
PY  - 2019///0521
KW  - Aniline Compounds
KW  - pharmacology
KW  - Antineoplastic Agents
KW  - Bridged Bicyclo Compounds, Heterocyclic
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - drug effects
KW  - Drug Resistance, Neoplasm
KW  - genetics
KW  - Humans
KW  - Oncogene Proteins, Fusion
KW  - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
KW  - drug therapy
KW  - Precursor Cell Lymphoblastic Leukemia-Lymphoma
KW  - Proto-Oncogene Proteins c-bcl-2
KW  - Receptor Tyrosine Kinase-like Orphan Receptors
KW  - Sulfonamides
KW  - Survival Rate
KW  - Translocation, Genetic
KW  - Up-Regulation
KW  - Wnt Signaling Pathway
KW  - Wnt-5a Protein
KW  - rhoA GTP-Binding Protein
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/s41388-018-0670-9
ER  -