TY  - GEN
AU  - Itkonen,Matti K
AU  - Tornio,Aleksi
AU  - Neuvonen,Mikko
AU  - Neuvonen,Pertti J
AU  - Niemi,Mikko
AU  - Backman,Janne T
TI  - Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans
SN  - 1521-009X
PY  - 2020///0123
KW  - Adult
KW  - Area Under Curve
KW  - Aryl Hydrocarbon Hydroxylases
KW  - metabolism
KW  - Biotransformation
KW  - physiology
KW  - Clopidogrel
KW  - pharmacology
KW  - Cross-Over Studies
KW  - Cytochrome P-450 CYP2C8
KW  - Cytochrome P-450 CYP2C8 Inhibitors
KW  - poisoning
KW  - Drug Interactions
KW  - Female
KW  - Gemfibrozil
KW  - Genotype
KW  - Glucuronides
KW  - Humans
KW  - Hypolipidemic Agents
KW  - Loratadine
KW  - analogs & derivatives
KW  - Male
KW  - Young Adult
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1124/dmd.118.084665
ER  -