TY  - GEN
AU  - Kari,Vijayalakshmi
AU  - Raul,Sanjay Kumar
AU  - Henck,Jana Maria
AU  - Kitz,Julia
AU  - Kramer,Frank
AU  - Kosinsky,Robyn Laura
AU  - Übelmesser,Nadine
AU  - Mansour,Wael Yassin
AU  - Eggert,Jessica
AU  - Spitzner,Melanie
AU  - Najafova,Zeynab
AU  - Bastians,Holger
AU  - Grade,Marian
AU  - Gaedcke,Jochen
AU  - Wegwitz,Florian
AU  - Johnsen,Steven A
TI  - The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness
SN  - 1868-7083
PY  - 2019///0820
KW  - Cell Line, Tumor
KW  - DNA Breaks, Double-Stranded
KW  - drug effects
KW  - Drug Resistance, Neoplasm
KW  - Epigenesis, Genetic
KW  - HCT116 Cells
KW  - Histone-Lysine N-Methyltransferase
KW  - Histones
KW  - metabolism
KW  - Humans
KW  - Methylation
KW  - Methyltransferases
KW  - antagonists & inhibitors
KW  - Phosphorylation
KW  - Prognosis
KW  - RNA, Small Interfering
KW  - pharmacology
KW  - Recombinational DNA Repair
KW  - Rectal Neoplasms
KW  - Small Molecule Libraries
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1186/s13148-018-0601-1
ER  -