TY  - GEN
AU  - Sampei,Zenjiro
AU  - Haraya,Kenta
AU  - Tachibana,Tatsuhiko
AU  - Fukuzawa,Taku
AU  - Shida-Kawazoe,Meiri
AU  - Gan,Siok Wan
AU  - Shimizu,Yuichiro
AU  - Ruike,Yoshinao
AU  - Feng,Shu
AU  - Kuramochi,Taichi
AU  - Muraoka,Masaru
AU  - Kitazawa,Takehisa
AU  - Kawabe,Yoshiki
AU  - Igawa,Tomoyuki
AU  - Hattori,Kunihiro
AU  - Nezu,Junichi
TI  - Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody
SN  - 1932-6203
PY  - 2019///0528
KW  - Animals
KW  - Antibodies, Monoclonal
KW  - genetics
KW  - Antibody Affinity
KW  - Complement Activation
KW  - drug effects
KW  - Complement C5
KW  - antagonists & inhibitors
KW  - Computer Simulation
KW  - Drug Discovery
KW  - methods
KW  - Endosomes
KW  - immunology
KW  - Histocompatibility Antigens Class I
KW  - Humans
KW  - Hydrogen-Ion Concentration
KW  - Immune System Diseases
KW  - drug therapy
KW  - Macaca fascicularis
KW  - Mice
KW  - Mice, Transgenic
KW  - Mutagenesis
KW  - Protein Engineering
KW  - Receptors, Fc
KW  - Recombinant Proteins
KW  - Time Factors
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.pone.0209509
ER  -