Chemoprevention in BRCA1 mutation carriers (CIBRAC): protocol for an open allocation crossover feasibility trial assessing mechanisms of chemoprevention with goserelin and anastrozole versus tamoxifen and acceptability of treatment. [electronic resource]
- BMJ open 12 2018
- e023115 p. digital
Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
2044-6055
10.1136/bmjopen-2018-023115 doi
Adult Anastrozole--therapeutic use Antineoplastic Agents, Hormonal--therapeutic use Breast Neoplasms--drug therapy Chemoprevention--methods Cross-Over Studies Disease-Free Survival Feasibility Studies Female Genetic Predisposition to Disease--epidemiology Goserelin--therapeutic use Heterozygote Humans Mutation Northern Ireland Patient Acceptance of Health Care--statistics & numerical data Patient Selection Premenopause--physiology Prognosis Risk Assessment Survival Rate Tamoxifen--therapeutic use Treatment Outcome Ubiquitin-Protein Ligases--genetics