TY  - GEN
AU  - Benjamin,Don
AU  - Robay,Dimitri
AU  - Hindupur,Sravanth K
AU  - Pohlmann,Jens
AU  - Colombi,Marco
AU  - El-Shemerly,Mahmoud Y
AU  - Maira,Sauveur-Michel
AU  - Moroni,Christoph
AU  - Lane,Heidi A
AU  - Hall,Michael N
TI  - Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells
SN  - 2211-1247
PY  - 2019///1203
KW  - Acids
KW  - metabolism
KW  - Animals
KW  - Cell Line, Tumor
KW  - Energy Metabolism
KW  - drug effects
KW  - Humans
KW  - Intracellular Space
KW  - Lactic Acid
KW  - Male
KW  - Metformin
KW  - pharmacology
KW  - Mice, Inbred C57BL
KW  - Monocarboxylic Acid Transporters
KW  - antagonists & inhibitors
KW  - Muscle Proteins
KW  - NAD
KW  - Neoplasms
KW  - Reserpine
KW  - analogs & derivatives
KW  - Symporters
KW  - Synthetic Lethal Mutations
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.celrep.2018.11.043
ER  -