Benjamin, Don <br/><br/>
Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.  [electronic resource] 

 -  Cell reports  12 2018 
 - 3047-3058.e4 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>2211-1247 
<br/><br/><label>Standard No.: </label>10.1016/j.celrep.2018.11.043  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Acids--metabolism<br/>Animals<br/>Cell Line, Tumor<br/>Energy Metabolism--drug effects<br/>Humans<br/>Intracellular Space--metabolism<br/>Lactic Acid--metabolism<br/>Male<br/>Metformin--pharmacology<br/>Mice, Inbred C57BL<br/>Monocarboxylic Acid Transporters--antagonists & inhibitors<br/>Muscle Proteins--antagonists & inhibitors<br/>NAD--metabolism<br/>Neoplasms--metabolism<br/>Reserpine--analogs & derivatives<br/>Symporters--antagonists & inhibitors<br/>Synthetic Lethal Mutations