TY  - GEN
AU  - Morishita,Ko
AU  - Shoji,Yoshimichi
AU  - Fukui,Masaki
AU  - Ito,Yuma
AU  - Kitao,Tatsuya
AU  - Ozawa,Shin-Ichiro
AU  - Hirono,Shuichi
AU  - Shirahase,Hiroaki
TI  - 2-Acyl-3-carboxyl-tetrahydroisoquinoline Derivatives: Mixed-Type PTP1B Inhibitors without PPARγ Activation
SN  - 1347-5223
PY  - 2018///1224
KW  - Animals
KW  - Diabetes Mellitus, Experimental
KW  - drug therapy
KW  - Dose-Response Relationship, Drug
KW  - Enzyme Inhibitors
KW  - blood
KW  - Humans
KW  - Hypoglycemic Agents
KW  - Male
KW  - Mice
KW  - Mice, Inbred Strains
KW  - Molecular Docking Simulation
KW  - Molecular Structure
KW  - PPAR gamma
KW  - metabolism
KW  - Protein Tyrosine Phosphatase, Non-Receptor Type 1
KW  - antagonists & inhibitors
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Structure-Activity Relationship
KW  - Tetrahydroisoquinolines
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1248/cpb.c18-00571
ER  -