Morishita, Ko <br/><br/>
2-Acyl-3-carboxyl-tetrahydroisoquinoline Derivatives: Mixed-Type PTP1B Inhibitors without PPARγ Activation.  [electronic resource] 

 -  Chemical & pharmaceutical bulletin  2018 
 - 1131-1152 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1347-5223 
<br/><br/><label>Standard No.: </label>10.1248/cpb.c18-00571  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Diabetes Mellitus, Experimental--drug therapy<br/>Dose-Response Relationship, Drug<br/>Enzyme Inhibitors--blood<br/>Humans<br/>Hypoglycemic Agents--blood<br/>Male<br/>Mice<br/>Mice, Inbred Strains<br/>Molecular Docking Simulation<br/>Molecular Structure<br/>PPAR gamma--metabolism<br/>Protein Tyrosine Phosphatase, Non-Receptor Type 1--antagonists & inhibitors<br/>Rats<br/>Rats, Sprague-Dawley<br/>Structure-Activity Relationship<br/>Tetrahydroisoquinolines--blood