Metabolic profiling of copper-laden hepatolenticular degeneration model rats and the interventional effects of Gandou decoction using UPLC-Q-TOF/MS. [electronic resource]
- Journal of pharmaceutical and biomedical analysis Feb 2019
- 187-195 p. digital
Publication Type: Journal Article
1873-264X
10.1016/j.jpba.2018.10.041 doi
Amino Acids--metabolism Animals Biomarkers--blood Chromatography, High Pressure Liquid--instrumentation Copper Sulfate--toxicity Disease Models, Animal Drugs, Chinese Herbal--pharmacology Glucose--metabolism Hepatolenticular Degeneration--chemically induced Humans Lipid Metabolism--drug effects Liver--drug effects Male Metabolic Networks and Pathways--drug effects Metabolome--drug effects Metabolomics--instrumentation Multivariate Analysis Principal Component Analysis Rats Tandem Mass Spectrometry--instrumentation Treatment Outcome