Adult Aged Bone Density Bone Density Conservation Agents--adverse effects Bone Remodeling Collagen Type I--metabolism Denosumab--adverse effects Double-Blind Method Drug Administration Schedule Female Headache--etiology Humans Male Middle Aged Osteoporosis--drug therapy Osteoprotegerin--metabolism Peptides--metabolism Placebo Effect RANK Ligand--metabolism Thalassemia--complications Treatment Outcome