TY - GEN AU - Katsyuba,Elena AU - Mottis,Adrienne AU - Zietak,Marika AU - De Franco,Francesca AU - van der Velpen,Vera AU - Gariani,Karim AU - Ryu,Dongryeol AU - Cialabrini,Lucia AU - Matilainen,Olli AU - Liscio,Paride AU - Giacchè,Nicola AU - Stokar-Regenscheit,Nadine AU - Legouis,David AU - de Seigneux,Sophie AU - Ivanisevic,Julijana AU - Raffaelli,Nadia AU - Schoonjans,Kristina AU - Pellicciari,Roberto AU - Auwerx,Johan TI - De novo NAD SN - 1476-4687 PY - 2019///0212 KW - Animals KW - Caenorhabditis elegans KW - cytology KW - Carboxy-Lyases KW - antagonists & inhibitors KW - Cell Line KW - Choline KW - Conserved Sequence KW - Disease Models, Animal KW - Evolution, Molecular KW - Female KW - Gene Knockdown Techniques KW - Health KW - Hepatocytes KW - Homeostasis KW - drug effects KW - Humans KW - Kidney KW - Liver KW - Longevity KW - Male KW - Methionine KW - deficiency KW - Mice KW - Mice, Inbred C57BL KW - Mitochondria KW - physiology KW - NAD KW - biosynthesis KW - Non-alcoholic Fatty Liver Disease KW - physiopathology KW - Rats KW - Sirtuins KW - metabolism N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/s41586-018-0645-6 ER -