Fukudo, Shin <br/><br/>
High-dose linaclotide is effective and safe in patients with chronic constipation: A phase III randomized, double-blind, placebo-controlled study with a long-term open-label extension study in Japan.  [electronic resource] 

 -  Neurogastroenterology and motility  01 2019 
 - e13487 p.  digital 
<br/><br/> Publication Type: Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1365-2982 
<br/><br/><label>Standard No.: </label>10.1111/nmo.13487  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adult<br/>Aged<br/>Chronic Disease<br/>Constipation--drug therapy<br/>Double-Blind Method<br/>Female<br/>Gastrointestinal Agents--therapeutic use<br/>Guanylyl Cyclase C Agonists--therapeutic use<br/>Humans<br/>Japan<br/>Male<br/>Middle Aged<br/>Peptides--therapeutic use