Linagliptin inhibits high glucose-induced transdifferentiation of hypertrophic scar-derived fibroblasts to myofibroblasts via IGF/Akt/mTOR signalling pathway. [electronic resource]
- Experimental dermatology 01 2019
- 19-27 p. digital
Publication Type: Journal Article
1600-0625
10.1111/exd.13800 doi
Actins--metabolism Adult Cell Proliferation Cell Transdifferentiation Cicatrix, Hypertrophic--drug therapy Collagen Type I--metabolism Collagen Type III--metabolism Fibroblasts--cytology Glucose Humans Insulin-Like Growth Factor I--metabolism Linagliptin--pharmacology Muscle, Smooth--metabolism Myofibroblasts--cytology Proto-Oncogene Proteins c-akt--metabolism Signal Transduction TOR Serine-Threonine Kinases--metabolism Wound Healing Young Adult