Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor. [electronic resource]
- Scientific reports 10 2018
- 14697 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2045-2322
10.1038/s41598-018-32910-4 doi
ADAM10 Protein--metabolism Amyloid Precursor Protein Secretases--metabolism Cell Membrane--metabolism Extracellular Matrix--metabolism HEK293 Cells Humans Ligands Low Density Lipoprotein Receptor-Related Protein-1--metabolism Mass Spectrometry Membrane Proteins--metabolism Protein Transport--physiology Proteomics Secretory Pathway--physiology Tissue Inhibitor of Metalloproteinase-3--metabolism