TY  - GEN
AU  - Imada,Takashi
AU  - Moriya,Koji
AU  - Uchiyama,Masahiko
AU  - Inukai,Naoto
AU  - Hitotsuyanagi,Mitsuhiro
AU  - Masuda,Akiko
AU  - Suzuki,Takehiro
AU  - Ayukawa,Shotaro
AU  - Tagawa,Yo-Ichi
AU  - Dohmae,Naoshi
AU  - Kohara,Michinori
AU  - Yamamura,Masayuki
AU  - Kiga,Daisuke
TI  - A Highly Bioactive Lys-Deficient IFN Leads to a Site-Specific Di-PEGylated IFN with Equivalent Bioactivity to That of Unmodified IFN-α2b
SN  - 2161-5063
PY  - 2019///1003
KW  - Animals
KW  - Antiviral Agents
KW  - blood
KW  - Directed Molecular Evolution
KW  - Humans
KW  - Interferon alpha-2
KW  - Interferon-alpha
KW  - chemistry
KW  - Lysine
KW  - deficiency
KW  - Mice
KW  - Mutagenesis, Site-Directed
KW  - Polyethylene Glycols
KW  - Protein Stability
KW  - Recombinant Proteins
KW  - biosynthesis
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/acssynbio.8b00188
ER  -