Imada, Takashi <br/><br/>
A Highly Bioactive Lys-Deficient IFN Leads to a Site-Specific Di-PEGylated IFN with Equivalent Bioactivity to That of Unmodified IFN-α2b.  [electronic resource] 

 -  ACS synthetic biology  11 2018 
 - 2537-2546 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>2161-5063 
<br/><br/><label>Standard No.: </label>10.1021/acssynbio.8b00188  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antiviral Agents--blood<br/>Directed Molecular Evolution<br/>Humans<br/>Interferon alpha-2<br/>Interferon-alpha--chemistry<br/>Lysine--deficiency<br/>Mice<br/>Mutagenesis, Site-Directed<br/>Polyethylene Glycols--chemistry<br/>Protein Stability<br/>Recombinant Proteins--biosynthesis