TY - GEN AU - Nangia,Varuna AU - Siddiqui,Faria M AU - Caenepeel,Sean AU - Timonina,Daria AU - Bilton,Samantha J AU - Phan,Nicole AU - Gomez-Caraballo,Maria AU - Archibald,Hannah L AU - Li,Chendi AU - Fraser,Cameron AU - Rigas,Diamanda AU - Vajda,Kristof AU - Ferris,Lorin A AU - Lanuti,Michael AU - Wright,Cameron D AU - Raskin,Kevin A AU - Cahill,Daniel P AU - Shin,John H AU - Keyes,Colleen AU - Sequist,Lecia V AU - Piotrowska,Zofia AU - Farago,Anna F AU - Azzoli,Christopher G AU - Gainor,Justin F AU - Sarosiek,Kristopher A AU - Brown,Sean P AU - Coxon,Angela AU - Benes,Cyril H AU - Hughes,Paul E AU - Hata,Aaron N TI - Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in SN - 2159-8290 PY - 2019///1223 KW - A549 Cells KW - Aniline Compounds KW - administration & dosage KW - Animals KW - Antineoplastic Agents KW - Antineoplastic Combined Chemotherapy Protocols KW - pharmacology KW - Apoptosis KW - drug effects KW - Benzamides KW - Carcinoma, Non-Small-Cell Lung KW - drug therapy KW - Cell Line, Tumor KW - Diphenylamine KW - analogs & derivatives KW - Humans KW - Lung Neoplasms KW - Mice, Knockout KW - Mice, Nude KW - Mice, SCID KW - Mitogen-Activated Protein Kinase Kinases KW - antagonists & inhibitors KW - Myeloid Cell Leukemia Sequence 1 Protein KW - Protein Kinase Inhibitors KW - Proto-Oncogene Proteins p21(ras) KW - Sulfonamides KW - Tumor Burden KW - Xenograft Model Antitumor Assays KW - methods N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1158/2159-8290.CD-18-0277 ER -