Lee, Wan-Hung

ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability. [electronic resource] - Molecular pain - 1744806918801224 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1744-8069

10.1177/1744806918801224 doi


Adaptor Proteins, Signal Transducing--antagonists & inhibitors
Animals
Animals, Newborn
Antineoplastic Agents--adverse effects
Cell Survival--drug effects
Cells, Cultured
Cerebral Cortex--cytology
Disease Models, Animal
Enzyme Inhibitors--therapeutic use
Female
Gene Expression Regulation, Neoplastic--drug effects
Green Fluorescent Proteins--genetics
HEK293 Cells
Humans
Hyperalgesia--drug therapy
Immunoprecipitation
Male
Mice
Mice, Inbred C57BL
Neoplasms--drug therapy
Neuralgia--chemically induced
Neurons
Nitric Oxide Synthase Type I--antagonists & inhibitors
Paclitaxel--adverse effects
Pain Threshold--drug effects
Rats
Transfection
Xenograft Model Antitumor Assays--methods